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Video Full Maria Camila Villalba Video On Twitter – Methadone or butorphanol as pre-anesthetic agents in combination with romipidine in horses undergoing elective surgery: a qualitative assessment of sedation and induction.

A fermented milk filtrate-based supplement for feeding newborn calves: effects on blood, growth performance and faecal parameters, including microorganism, volatile compounds and fatty and organic acid profiles.

Video Full Maria Camila Villalba Video On Twitter

Video Full Maria Camila Villalba Video On Twitter

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Data Collection Study for the Fourth Confidential Multicenter Perioperative Equine Mortality Trial (CEPEF4): New Technique and Preliminary Results

By Miguel Gozalo-Marcilla 1, * , Regula Bettschart-Wolfensberger 2 , Mark Johnston 3 , Polly M. Taylor 4 and Jose I. Redondo 5

Veterinary Clinical Sciences, Royal (Dick) School of Veterinary Medicine and Roslyn Institute, Easter Bush Campus, University of Edinburgh, Edinburgh EH25 9RG, UK

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Received: July 5, 2021 / Revised: August 23, 2021 / Accepted: August 25, 2021 / Published: August 30, 2021

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New technologies allow researchers to improve methods for data collection, cleaning and immediate and accurate analysis, with minimal geographic limitations. Although much progress has been made in equine anesthesia in recent years, we are still far from reducing anesthesia-related mortality in this species compared to anesthesia in small animals. The purpose of this multicenter study was to investigate the utility of a web-based method for data presentation and outcome reporting in horses undergoing general anesthesia and the use of an electronic questionnaire and statistical software for certain procedures using stable sedation. Within six months, 8656 cases were collected from 69 centers: 6701 procedures under full anesthesia and 1955 under permanent sedation. The results demonstrate (i) the usefulness of the method and (ii) that some horses died unexpectedly while not only under general anesthesia, but also soundly asleep. Finally, (iii) we present some descriptive data describing current anesthesia practice compared to the previous CEPEF2. We concluded that our web-based method is suitable for this type of research. New techniques can reduce mortality. However, the results presented here should be interpreted with caution as they are only preliminary data with lower numbers than CEPEF2.

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It has been almost 20 years since the largest multicenter, observational study to assess mortality risks associated with general anesthesia in horses. We proposed a web-based method for data collection (cleaned and analyzed with R) to assess perioperative equine mortality in a multicenter, cohort, observational, analytical, longitudinal, prospective study. The objective was to report the utility of the illustrated method with preliminary data, including results for horses seven days after general anesthesia and certain procedures using stable sedation. Over a period of six months, data were collected from 6701 procedures under general anesthesia and 1955 stable sedations from 69 centers. The results showed (i) the usefulness of the method; Furthermore, (ii) overall mortality under general anesthesia was 1.0% during the seven-day outcome period. In horses that underwent procedures other than exploratory laparotomy for colic (“nocolic”), the rate was lower, 0.6%, and in “colic” it was higher, 3.4%. For stable sleepers, the overall mortality rate is 0.2%. Finally, (iii) we present some descriptive data showing new developments since the previous CEPEF2. Finally, horses still die unexpectedly when undergoing procedures under general anesthesia or under sedation. Our method is suitable for collecting cases for future studies.

Anesthesia; CEPEF; Data Analysis; deceased persons; epidemiology; equestrian; horse; death rate; stable sedation anesthesia; CEPEF; Data Analysis; deceased persons; epidemiology; equestrian; horse; death rate; Constant relaxation

Web-based research has become common over the past 10-20 years, and online data collection from large groups of participants with few geographic boundaries is possible. Online data collection is fast, cost-effective and increases the accuracy and efficiency of data entry [1]. Furthermore, data can be analyzed interactively with the possibility of follow-up with the participants [1, 2, 3]. Appropriate statistical software for data analysis and cleaning is a must, besides expertise in how to use the new technology and adapting the research design to data collection [4, 5]. Immediate technical support and ongoing communication between managers and participants is very important.

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The mortality risk associated with general anesthesia in horses is one of the greatest concerns for equine physicians and veterinarians. Many studies report mortality risks associated with anesthesia. Most of these studies were retrospective [6, 7, 8, 9, 10, 11, 12, 13, 14] but few were prospective, single-center [15] and some were prospective, multicenter [16, 17] investigations. Done. To date, the Confidential Investigation into Perioperative Equine Fatalities 2 (CEPEF2), published in 2002, remains the largest observational, multicenter study that collected 41,824 patients from 62 clinics over a 6-year period [18]. Overall mortality up to seven days was 1.9%, 0.9% without colic and 7.8% with colic [18]. Although much has changed since then, we are still far from reducing these numbers [19], and the need to update CEPEF data was expressed eight years ago [20]. Avoiding general anesthesia may reduce mortality by performing certain procedures in standing horses, but there are no data yet to support this hypothesis.

The first objective of this report was to describe the utility of a network-based method and data cleaning strategy for data collection for the CEPEF4 study, the ultimate objective of which was to identify risk factors associated with equine anesthesia and stable sedation. Second, reporting and analysis of key baseline findings within seven days of outcome/mortality in horses of certain procedures performed under (i) general anesthesia and (ii) permanent sedation during the first six months of CEPEF4. in detail in the future. Our first hypothesis was that the proposed method would be a fast and reliable tool for collecting, cleaning and analyzing data. Second, the mortality rate was lower than that reported by Johnston et al. About 20 years ago [18] and permanent sedation procedures are not free from the risk of death, although it is low. Finally, we hypothesized that there would be trends for new uses of anesthesia and analgesia compared to the previous CEPEF2.

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The research design was multicenter, cohort, observational, analytical, longitudinal and prospective. For this phase of the preliminary results, the six-month data collection period was from November 1, 2020 to April 30, 2021.

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Inclusion criteria include horses, mules and mules of all ages from clinics around the world specifically recruited for this project. Horses All cases from each participating clinic were (i) regardless of cause (i) general anesthesia and (ii) surgery required stable sedation or a continuous course of advanced diagnostic imaging (MRI), computed tomography (CT) or scintigraphy. infusion (CRI) or at least one supplement in addition to the initial sedation bolus. After recording began in each clinic, all cases had to be entered. However, on holidays and staff absence, all cases can be omitted within a specified period; The reporting and delivery of all cases was resumed after the specified period.

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The exclusion criteria were cases outside of agreed recording periods, targeted cases that did not follow the communication process and targeted cases that did not send all the files during the recording period. General anesthesia for peripheral procedures, as well as permanent sedation without augmentation or CRI and permanent sedation for other reasons such as surgery or advanced diagnostic imaging, cast changes or sinoscopy were excluded.

A user-friendly online questionnaire used in small animals [21] was adapted for this equine study using feedback from a group of researchers and clinicians with a special interest in equine anesthesia and analgesia [22]. It is intended to be used to collect information for both general anesthesia and stable sedation.

Briefly, the questionnaire collected data at the center, level

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